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Oncotarget 10:11021118

Very long chain (C22C24) ceramides are synthesized by ceramide synthase 2 (CerS2) and a CerS2 null mouse displays hepatopathy because of depletion of C22C24 ceramides, elevation of C16-ceramide and/or elevation of sphinganine [89]

Japan Patent Application JP2012213361 (A) Hara KY, Aoki N, Kobayashi J, Kiriyama K, Nishida K, Araki M, Kondo A (2015) Improvement of oxidized glutathione fermentation by thiol redox metabolism engineering in Saccharomyces cerevisiae

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This integrated view, backed by published literature and emerging evidence, strongly suggests a self-perpetuating vicious cycle, where each component can initiate and amplify the others, ultimately fuelling disease progression